AGING CELL

中文简介

概述老化细胞的目标是发表高质量的，创新的研究解决衰老生物学的基本问题。为了在《衰老细胞》杂志上发表，这项工作必须为理解衰老做出重大的新贡献，并引起社会的普遍兴趣。《衰老细胞》试图涵盖老年科学的所有领域，强调揭示衰老过程的机械方面的研究，以及衰老与年龄相关疾病之间的联系。将考虑对没有实质力学见解的新老化过程的观察，但对该领域应具有特别高的影响。主题包括但不限于，营养反应信号通路，神经和内分泌信号通路，组织相互作用，遗传和表观遗传调控和完整性，蛋白质平衡，昼夜节律，活性氧和线粒体，细胞衰老，干细胞，progerias和干预，影响老化是鼓励。所有的实验方法，包括植物模型，都是受欢迎的。关注特定年龄相关病理的发病机制的论文也很有趣，但应该对衰老和疾病之间的基本联系提供新的见解。目标和范围衰老细胞覆盖:遗传学和功能基因组学:影响寿命的突变;基因的同源性;机体和细胞老化;基因操作。信号和基因表达:与年龄相关的变化与表型和生理联系的机制;胞内信号;细胞与组织的相互作用;激素、免疫和炎症系统。细胞增殖、衰老与死亡:复制性衰老;细胞凋亡;端粒生物学等内外因素的影响;时间细胞老化;老化细胞的表型。细胞应激和损伤:自由基对细胞和组织的外在和内在影响;自由基防御与损伤;自由基作为信号分子;压力和衰老。干细胞与衰老:年龄对干细胞生成的影响迁移和体内平衡;茎cell-niche交互;监管机制。综合生理学:机体、细胞和分子水平衰老过程的结果。生物人口学与比较研究:人口与跨物种比较研究。老年与长寿新理论:在已建立和新颖的老年与长寿理论的最广泛层面上的讨论。《衰老细胞》创刊于2002年，双月刊。文章类型包括:新颖的，同行评审的研究，集中在上述领域。对近期备受瞩目的研究进行评估。评注对期刊或其他主要期刊上当前特别重要的论文进行评价的评注。生物老化一般理论的发展与批判。关键字衰老，衰老，长寿，寿命，细胞衰老，细胞死亡，细胞凋亡，压力，自由基，端粒酶，端粒，老年学，老年医学抽象和索引信息学术检索(EBSCO出版)学术搜索校友版(EBSCO出版)学术搜寻总理(EBSCO出版)CAS:化学文摘服务(ACS)CSA生物科学数据库(ProQuest)Embase(爱思唯尔)InfoTrac(盖尔Cengage)Ingenta选择ISI提醒服务期刊引用报告/科学版(Clarivate Analytics)MEDLINE / PubMed(NLM)神经科学抽象(它)ProQuest生物科学收藏(ProQuest)PubMed膳食补充剂子集(NLM)科学引文索引扩展(Clarivate Analytics)

英文简介

OverviewThe aim of Aging Cell is to publish the highest quality, innovative research addressing fundamental issues in the biology of aging. For publication in Aging Cell, the work must provide a major new contribution to the understanding of aging and be of general interest to the community. Aging Cell seeks to cover all areas of geroscience, highlighting research that uncovers mechanistic aspects of the aging process, as well as the links between aging and age-related disease. Observations of novel aging processes without substantial mechanistic insight will be considered, but should be of especially high impact for the field. Topics including, but not limited to, nutrient-responsive signaling pathways, neuronal and endocrine signaling pathways, tissue interactions, genetic and epigenetic regulation and integrity, proteostasis, circadian rhythms, ROS and mitochondria, cellular senescence, stem cells, progerias and interventions that affect aging are encouraged. All experimental approaches, including plant models, are welcome. Papers that focus on the pathogenesis of a specific age-related pathology are also of interest, but should offer new insights into the fundamental links between aging and disease.Aims and ScopeAging Cell covers:Genetics and functional genomics: mutations affecting longevity; gene homologies; organismal and cellular aging; gene manipulation.Signaling and gene expression: mechanisms linking age-associated changes with phenotypes and physiology; intracellular signaling; interactions between cells and tissues; hormonal, immune, and inflammatory systems.Cell proliferation, aging and death: replicative senescence; apoptosis; telomere biology and other intrinsic and extrinsic influences; chronological cellular aging; phenotypes of aging cells.Cell stress and damage: extrinsic and intrinsic influences of free radicals on cells and tissues; free radical defense and damage; free radicals as signaling molecules; stress and aging.Stem cells and aging: effects of age on stem cell generation; migration and homeostasis; stem cell-niche interactions; regulatory mechanisms.Integrative physiology: outcomes of aging processes at organismal, cellular and molecular levels.Biodemography and comparative studies: population and cross-species comparative studies.New theories of aging and longevity: discussion at the broadest level of established and novel theories of aging and longevity.Aging Cell was launched in 2002 and is published bimonthly. Article types include:Novel, peer-reviewed research, concentrating in the areas described above.Reviews and minireviews assessing high-profile recent research.Commentaries evaluating especially important current papers in the Journal or other leading journals.Development and criticism of general theories of biological aging.KeywordsAging, ageing, longevity, lifespan, cell senescence, cell death, apoptosis, stress, free radicals, telomerase, telomeres, gerontology, geriatric Abstracting and Indexing InformationAcademic Search (EBSCO Publishing)Academic Search Alumni Edition (EBSCO Publishing)Academic Search Premier (EBSCO Publishing)CAS: Chemical Abstracts Service (ACS)CSA Biological Sciences Database (ProQuest)Embase (Elsevier)InfoTrac (GALE Cengage)Ingenta SelectISI Alerting ServicesJournal Citation Reports/Science Edition (Clarivate Analytics)MEDLINE/PubMed (NLM)Neurosciences Abstracts (ProQuest)ProQuest Biological Science Collection (ProQuest)PubMed Dietary Supplement Subset (NLM)Science Citation Index Expanded (Clarivate Analytics)